Ciclosporin Impurity 21 CAS CATO-C4X-199821
| CAS No. | CATO-C4X-199821 |
| Molecular Formula | C63H111N11O12 |
| Molecular Weight | 1214.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ciclosporin Impurity 21 (CAS CATO-C4X-199821, C63H111N11O12) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ciclosporin Impurity 21 (C63H111N11O12) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C63H111N11O12 |
| Molecular Weight | 1214.62 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 11 |
Related Ciclosporin Standards
- Ciclosporin Impurity 11 (CAS CATO-C4X-199811)
- Ciclosporin EP Impurity G (CAS 63775-96-2)
- Ciclosporin EP Impurity B (CAS 59865-15-5)
- Ciclosporin EP Impurity C (CAS 59865-16-6)
- Ciclosporin Impurity 12 (CAS CATO-C4X-199812)
- Ciclosporin Impurity 23 (CAS CATO-C4X-199823)
- Ciclosporin Impurity 19 (CAS CATO-C4X-199819)
- Ciclosporin Impurity 20 (CAS CATO-C4X-199820)
Recommended Standards
- Voclosporin (CAS 515814-01-4)
- Valspodar (CAS 121584-18-7)
- Voclosporin Impurity 4 (CAS 121584-34-7)
- m-PEG24-NHS ester (CAS 2395839-96-8)
- Rufinamide Impurity 6 (CAS 869501-51-9)
- Avatrombopag Impurity 5 (CAS 1290121-42-4)
- Dapagliflozin Impurity 66 (CAS 714269-58-6)
- [1,1′-Biphenyl]-4-sulfinic acid, sodium salt (1:1) (CAS 131419-12-0)
- (4-(Benzyloxy)-2-bromo-5-methoxyphenyl)methanol (CAS 65341-82-4)
- 2-Imidazol-1-ylmethyl-benzoic acid hydrochloride (CAS 1185293-25-7)
- Cyclopropane-1,1,2,2,3,3-hexacarboxylic acid hexamethyl ester, 98% (CAS 109777-05-1)
- trans-4-(Hydroxymethyl)cyclohexanecarboxylic Acid (CAS 66185-74-8)
- 2-(2,5-Difluorophenyl)pyrrolidine hydrochloride (CAS 1197238-95-1)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
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