Vortioxetine Impurity 111 CAS 640767-44-8
| CAS No. | 640767-44-8 |
| Molecular Formula | C14H15NS |
| Molecular Weight | 229.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Vortioxetine Impurity 111 (CAS 640767-44-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H15NS and a molecular weight of 229.34 g/mol.
The molecular framework of Vortioxetine Impurity 111 (C14H15NS) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15NS |
| Molecular Weight | 229.34 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Vortioxetine Standards
- Vortioxetine Impurity 112 (CAS 33264-60-7)
- Vortioxetine Impurity 143 (CAS CATO-C4X-1056143)
- Vortioxetine Impurity 163 (CAS CATO-C4X-1056164)
- Vortioxetine Impurity 59 (CAS 900641-61-4)
- Vortioxetine Impurity 89 (CAS 1019453-85-0)
- Vortioxetine Impurity 44 (CAS CATO-C4X-105644)
- Vortioxetine Impurity 73 (CAS 66698-28-0)
- Vortioxetine Impurity 2 (CAS 1011-13-8)
Recommended Standards
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- (2-Methoxynaphthalen-1-yl)methanol (CAS 40696-22-8)
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