Carvedilol Impurity 16 CAS 64464-07-9
| CAS No. | 64464-07-9 |
| Molecular Formula | C9H13NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Carvedilol Impurity 16.
Carvedilol Impurity 16 (CAS 64464-07-9) is a certified pharmaceutical impurity reference standard with the molecular formula C9H13NO2HCl and a molecular weight of 203.67 g/mol.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Carvedilol Impurity 16 is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 203.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H13NO2 HCl |
| Molecular Weight | 203.67 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Carvedilol Standards
- Carvedilol-d3 (CAS 1020719-25-8)
- Carvedilol Impurity 27 (CAS 1059573-38-4)
- Carvedilol Impurity 34 (CAS 1059573-45-3)
- Carvedilol Impurity 25 (CAS 1076199-79-5)
- (±)-Carvedilol-d4 (CAS 1133705-56-2)
- Carvedilol -D-Glucuronide (CAS 114869-83-9)
- Carvedilol Impurity 35 (CAS 1187921-93-2)
- Carvedilol impurity 9 (CAS 1198090-71-9)
Recommended Standards
- Cefpirome Impurity 43 (CAS CATO-C4X-120743)
- Loxoprofen Impurity 67 (CAS 32454-35-6)
- Moxifloxacin EP Impurity A HCl (CAS 151282-23-4)
- 5-Bromo-3-iodothiophene-2-carboxylic acid (CAS 1389315-17-6)
- Methyl 4-hydroxy-2,3-dihydrobenzofuran-6-carboxylate (CAS 1780699-08-2)
- 4,6,7-Trimethoxyfuro[2,3-b]quinoline (CAS 484-08-2)
- tert-Butyl 4-(4-aminophenylsulfonyl)piperazine-1-carboxylate (CAS 173951-84-3)
- 5-(3,5-Dichlorophenyl)nicotinonitrile (CAS 1346692-01-0)
- 2-Bromospiro[fluorene-9,2'-[1,3]dioxolane] (CAS CATO-CIM-101728)
- (D-Tyr1,N-Me-Phe3)-Neuropeptide FF (H-4752.0001) (CAS 145274-93-7)
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