Loxoprofen Impurity 67 CAS 32454-35-6
| CAS No. | 32454-35-6 |
| Molecular Formula | C10H11BrO2 |
| Molecular Weight | 243.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Loxoprofen Impurity 67 (CAS 32454-35-6, C10H11BrO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system, Loxoprofen Impurity 67 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 243.10 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11BrO2 |
| Molecular Weight | 243.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Br-containing |
Related Loxoprofen Standards
- Loxoprofen impurity 103 (CAS CATO-C4X-1488103)
- Loxoprofen Impurity 50 (CAS 111128-12-2)
- Loxoprofen Impurity 71 (CAS CATO-C4X-148871)
- Loxoprofen impurity 118 (CAS CATO-C4X-1488118)
- Loxoprofen impurity 119 (CAS CATO-C4X-1488119)
- Loxoprofen Impurity 147 (CAS CATO-C4X-1488147)
- Loxoprofen Impurity 148 (CAS CATO-C4X-1488148)
- Loxoprofen Impurity 154 (CAS 90319-74-7)
Recommended Standards
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- Valaciclovir EP Impurity J (CAS 142963-63-1)
- ((3S,4S)-3-fluoropiperidin-4-yl)methanol (CAS 1932343-28-6)
- N-(5-Bromo-2-pyridinyl)-N-(3-methylphenyl)amine (CAS 1219964-39-2)
- Rocuronium Impurity 43 (CAS CATO-C4X-124243)
- 3-Nitro-4-methylphenylacetic Acid (CAS 54941-44-5)
- N-(2-Cyano-3-methylbutan-2-yl)-2-((4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 790288-46-9)
- 2-(Methylsulfonyl)-5-nitrophenol (CAS 1820684-10-3)
- Tirzepatide Impurity 43 (CAS CATO-C4X-324043)
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