Etoricoxib impurity 56 CAS 646459-51-0
| CAS No. | 646459-51-0 |
| Molecular Formula | C26H22ClNO4S2 |
| Molecular Weight | 512.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Etoricoxib impurity 56 (CAS 646459-51-0, C26H22ClNO4S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Etoricoxib impurity 56 (C26H22ClNO4S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Etoricoxib impurity 56 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H22ClNO4S2 |
| Molecular Weight | 512.04 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Etoricoxib Standards
- Etoricoxib impurity 53 (CAS 646459-43-0)
- Etoricoxib impurity 54 (CAS 646459-47-4)
- Etoricoxib impurity 55 (CAS 646459-40-7)
- Etoricoxib Impurity 21 (CAS CATO-C4X-108021)
- Etoricoxib Impurity 33 (CAS 1817735-82-2)
- Etoricoxib Impurity 92 (CAS CATO-C4X-108092)
- Etoricoxib Impurity 50 (CAS CATO-C4X-108050)
- Etoricoxib Impurity 12 (CAS CATO-C4X-108012)
Recommended Standards
- N-(4-Chlorophenyl)-2-((3-(4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 618431-94-0)
- Dasatinib-d8 N-Oxide (CAS 1189988-36-0)
- N-(3-Chlorophenyl)-2-((3-(4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 477330-67-9)
- 4-Benzyloxy Toremifene (CAS 176671-79-7)
- Landiolol Impurity N11 HCl (CAS 1253907-81-1)
- Nebivolol Impurity 104 (CAS 1345202-52-9)
- Vazegepant Impurity 12 (CAS CATO-C4X-320012)
- Rimegepant Impurity 157 (CAS CATO-C4X-2487157)
- Olmesartan Impurity 44 (CAS CATO-C4X-109744)
- 2-Bromo-4-(trifluoromethyl)thiazole-5-carboxamide (CAS 1823883-11-9)
- 3-(Bis(2-hydroxyethyl)amino)-5-(trifluoromethyl)picolinonitrile (CAS 1672655-86-5)
- Bromo-PEG3-phosphonic acid diethyl ester (CAS 1148026-98-5)
- 4,5-Dichloro-2-methylbenzaldehyde (CAS 1416352-12-9)
- Crustacean Cardioactive Peptide (CAS 107090-96-0)
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