Etoricoxib impurity 54 CAS 646459-47-4
| CAS No. | 646459-47-4 |
| Molecular Formula | C25H22ClN3O5S2 |
| Molecular Weight | 544.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Etoricoxib impurity 54 (CAS 646459-47-4) is a certified pharmaceutical impurity reference standard with the molecular formula C25H22ClN3O5S2 and a molecular weight of 544.04 g/mol.
Etoricoxib impurity 54 (C25H22ClN3O5S2) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Etoricoxib impurity 54 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H22ClN3O5S2 |
| Molecular Weight | 544.04 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Etoricoxib Standards
- Etoricoxib impurity 53 (CAS 646459-43-0)
- Etoricoxib Impurity 50 (CAS CATO-C4X-108050)
- Etoricoxib impurity 56 (CAS 646459-51-0)
- Etoricoxib impurity 55 (CAS 646459-40-7)
- Etoricoxib Impurity 21 (CAS CATO-C4X-108021)
- Etoricoxib Impurity 33 (CAS 1817735-82-2)
- Etoricoxib Impurity 92 (CAS CATO-C4X-108092)
- Etoricoxib Impurity 12 (CAS CATO-C4X-108012)
Recommended Standards
- 3,4,5-Tribromo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamide (CAS 1023524-35-7)
- Chloro{(1R,2R)-1,2-diphenyl-1-[(3-(η6-phenyl)propyl)amino]-2-(methylsulfonylamido)}ruthenium(II) (CAS 1361415-88-4)
- (7-Chloro-3-methyl-4-oxo-6-((prop-2-ynyl(4-(pyridin-3-ylmethylcarbamoyl)phenyl)amino)methyl)-3,4-dihydroquinazolin-2-yl)methyl acetate (CAS 1258400-23-5)
- Chloro{(1S,2S)-1,2-diphenyl-1-[(3-(η6-phenyl)propyl)amino]-2-(methylsulfonylamido)}ruthenium(II) (CAS 1437326-26-5)
- Minoxidil Impurity 15 (CAS CATO-C4X-170015)
- Lumateperone impurity 63 (CAS CATO-C4X-220163)
- Dabigatran Impurity 121 (CAS CATO-C4X-1089121)
- 5-Isopropyl-2-methyl-1,3-dinitrobenzene (CAS 99068-90-3)
- 4’-Butyl-2-hydroxyacetophenone (CAS 1480233-72-4)
- Methyl 3-amino-3-(3-(benzyloxy)phenyl)propanoate (CAS 1146295-10-4)
- 6-Amino-2-chloropyridine-3-thiol (CAS 2374137-52-5)
- 1-(2-Fluorophenyl)piperazine (CAS 1011-15-0)
- 2,3-O-Isopropylidene-α-L-sorbofuranose (CAS 17682-71-2)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com