2-(2,6-Difluorophenyl)acetonitrile CAS 654-01-3
| CAS No. | 654-01-3 |
| Molecular Formula | C8H5F2N |
| Molecular Weight | 153.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(2,6-Difluorophenyl)acetonitrile is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(2,6-Difluorophenyl)acetonitrile (CAS 654-01-3) is a high-purity analytical reference standard with the molecular formula C8H5F2N and a molecular weight of 153.13 g/mol.
The molecular framework of 2-(2,6-Difluorophenyl)acetonitrile (C8H5F2N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 2-(2,6-Difluorophenyl)acetonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5F2N |
| Molecular Weight | 153.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenyl Standards
- 2-(2,4-Difluorophenyl)acetonitrile (CAS 656-35-9)
- 2-(2,5-Difluorophenyl)acetonitrile (CAS 69584-87-8)
- 2-(3,4-Difluorophenyl)acetonitrile (CAS 658-99-1)
- n-(3,4-Difluorophenyl)cyanamide (CAS 1251343-38-0)
- 3-(2,4-Difluorophenyl)-1-propene (CAS 951893-28-0)
- 3-(3,5-Difluorophenyl)-1-propene (CAS 79538-22-0)
- 3,4-Difluorophenyl Isocyanate (CAS 42601-04-7)
- 2-(2,6-Difluorophenyl)acetaldehyde (CAS 109346-83-0)
Recommended Standards
- 2-(Difluoromethyl)benzonitrile (CAS 799814-30-5)
- (S)-Methyl 2-amino-4,4-difluorobutanoate (CAS 607403-55-4)
- 2,2-Difluoro-2-phenylacetonitrile (CAS 2002-72-4)
- (S)-Ethyl 2-amino-3,3-difluoropropanoate (CAS 773046-41-6)
- 4-(2-Bromopropyl)-3-methylpyridine (CAS 1341882-08-3)
- 3-Amino-1-cyclopropylpiperidin-2-one (CAS 1343652-40-3)
- N-Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine (CAS 181951-92-8)
- Methyl 3-[(5-Bromo-2-fluorophenyl)amino]-2,2-dimethyl-3-oxopropionate (CAS 1890113-34-4)
- 4-Butylthiazole-5-carboxylic acid (CAS 1267076-42-5)
- 1,2-dibromo-3-methyl-5-nitrobenzene (CAS 73557-64-9)
- N-benzyl-1-(pyrimidin-5-yl)methanamine (CAS 1341460-36-3)
- 4-(((tert-Butyldimethylsilyl)oxy)methyl)piperidine (CAS 204580-41-6)
- Linagliptin Impurity 77 (CAS 1673546-62-7)
- [5-31]-Semaglutide (CAS CATO-C4X-2226263)
Why CATO?
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