1,3-Difluoro-2-methoxy-5-methylbenzene CAS 654-09-1
| CAS No. | 654-09-1 |
| Molecular Formula | C8H8F2O |
| Molecular Weight | 158.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 1,3-Difluoro-2-methoxy-5-methylbenzene (CAS 654-09-1), a certified reference material (molecular formula C8H8F2O, MW 158.15 g/mol) for analytical method development and quality control.
Owing to a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 1,3-Difluoro-2-methoxy-5-methylbenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 158.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1,3-Difluoro-2-methoxy-5-methylbenzene under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H8F2O |
| Molecular Weight | 158.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 1,3-Difluoro-2-(methoxymethyl)benzene (CAS 110213-71-3)
- (1s)-2,2-Difluoro-1-phenylethan-1-ol (CAS 123986-75-4)
- 5,6-Difluoro-N1-methylbenzene-1,2-diamine (CAS 1248508-73-7)
- 3,5-Difluoro-4-methylanisole (CAS 1261478-94-7)
- 1,4-Difluoro-2-methoxy-5-methylbenzene (CAS 1261760-78-4)
- 2,2-Difluoro-2-phenylethanol (CAS 129973-51-9)
- (4,5-Difluoro-2-methylphenyl)methanol (CAS 1378624-91-9)
- (3,5-Difluoro-2-methylphenyl)methanol (CAS 1378666-27-3)
Recommended Standards
- 1,3-Difluoro-2-methoxy-4-methylbenzene (CAS 261763-33-1)
- 1,3-Difluoro-5-(methoxymethyl)benzene (CAS 228122-40-5)
- 1,2-Dimethylcyclopropane-1,2-dicarboxylic acid (CAS 89898-46-4)
- 1-Ethoxy-2,4-difluorobenzene (CAS 348-20-9)
- Methyl 2-(1-(2-chlorophenyl)-5-oxo-2,5-dihydro-1H-pyrazol-3-yl)acetate (CAS 1158233-60-3)
- N-Cyclohexyl-5,6-diphenylpyridazin-3-amine (CAS 321359-43-7)
- (R)-3-Acetoxyquinuclidine (CAS 59653-40-6 (free base))
- Ritlecitinib malonate, >98% (HPLC) (CAS 2140301-97-7)
- 1-(4-Chlorophenyl)-1H-pyrazole-4-sulfonamide (CAS 1249520-94-2)
- 3,7,8-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one (CAS 1429-28-3)
- 6-Acetyl-4-(p-tolylamino)quinoline-3-carbonitrile (CAS 1956331-65-9)
- 1-(Pyrimidin-2-yl)piperidine-3-carboxylic acid hydrochloride (CAS 1185296-02-9)
- 3-Iodo-1H-pyrrolo[2,3-c]pyridine-4-carbonitrile (CAS 1190310-26-9)
- Peptide Impurity 26 (CAS 1350456-66-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com