Linagliptin Impurity 77 CAS 1673546-62-7
| CAS No. | 1673546-62-7 |
| Molecular Formula | C27H27F3N8O3 |
| Molecular Weight | 568.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Linagliptin Impurity 77 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Linagliptin Impurity 77 (CAS 1673546-62-7) is a certified pharmaceutical impurity reference standard with the molecular formula C27H27F3N8O3 and a molecular weight of 568.55 g/mol.
The molecular framework of Linagliptin Impurity 77 (C27H27F3N8O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Linagliptin Impurity 77 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H27F3N8O3 |
| Molecular Weight | 568.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Linagliptin Standards
- Linagliptin Impurity 123 (CAS CATO-C4X-1101123)
- Linagliptin impurity 143 (CAS 2517759-32-7)
- Linagliptin Impurity 159 (CAS CATO-C4X-1101159)
- Linagliptin Impurity 18 (CAS 668273-74-3)
- Linagliptin Impurity 46 (CAS 668273-75-4)
- Linagliptin Impurity 69 (CAS CATO-C4X-110169)
- Linagliptin Impurity N13 (CAS 2138392-83-1)
- Linagliptin impurity N2 (CAS 1446263-39-3)
Recommended Standards
- 2-((3S,5S,6R)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid (CAS 2459946-14-4)
- 1,1,1-Tris(diphenylphosphino)methane (CAS 28926-65-0)
- tert-butyl (E)-2-((3,3-dimethylbutylidene)amino)acetate (CAS 1447813-21-9)
- [(2R,3R,4R,5R,6R)-5-acetamido-3,4-diacetoxy-6-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]tetrahydropyran-2-yl]methyl acetate (CAS 1261568-35-7)
- Bromfenac Impurity 48 (CAS CATO-C4X-200248)
- Atorvastatin EP Impurity F (CAS 1371615-56-3)
- Clenbuterol impurity 7 (CAS 2383807-57-4)
- Methyl 7-(tert-butyldimethylsilyloxy)-2-fluoroheptanoate (CAS 1864056-66-5)
- 4-Bromo-2-(difluoromethyl)-5-(trifluoromethyl)aniline (CAS 1805104-57-7)
- 5-((5-(Trifluoromethyl)pyridin-2-yl)sulfonyl)thiophene-2-sulfonyl chloride (CAS 175202-87-6)
- 1-(5-Bromo-2-chloropyridin-4-yl)ethanol (CAS 1823421-44-8)
- 2-(Difluoromethyl)-4-nitropyridine-6-methanol (CAS 1804695-09-7)
- 5-Chloro-2-methyl-1H-benzo[d]imidazol-7-ol (CAS 1395040-91-1)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
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