Bedaquiline Impurity 4 CAS 654655-69-3
| CAS No. | 654655-69-3 |
| Molecular Formula | C17H14BrNO |
| Molecular Weight | 328.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Bedaquiline Impurity 4 (CAS 654655-69-3), a pharmacopoeial impurity reference standard (molecular formula C17H14BrNO, MW 328.20 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Bedaquiline Impurity 4 (C17H14BrNO) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H14BrNO |
| Molecular Weight | 328.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bedaquiline Standards
- Bedaquiline Impurity 16 (CAS 918648-51-8)
- Bedaquiline Impurity 17 (CAS 918518-83-9)
- Bedaquiline Impurity 63 (CAS 2813341-31-8)
- Bedaquiline Impurity 5 (CAS 654655-68-2)
- Bedaquiline Impurity 4 (CAS 924633-09-0)
- Bedaquiline Impurity N1 (CAS 39648-67-4)
- Bedaquiline Impurity 1 (CAS 349537-52-6)
- Bedaquiline Impurity 6 (CAS 316146-27-7)
Recommended Standards
- 4120AF 5-Bromo-2-(1-naphthylmethoxy)phenylamine 946743-28-8 C17H14BrNO (CAS 946743-28-8)
- Fluorodifen (CAS 15457-05-3)
- tert-Butyl 3-(4-bromophenoxy)azetidine-1-carboxylate (CAS 960402-39-5)
- 4-(4-Bromophenyl)-1-tosyl-1H-pyrazol-5-amine (CAS 1013837-41-6)
- Xanomeline impurity 55 (CAS CATO-C4X-330155)
- Butylphthalide Impurity N2 (CAS 20320-37-0)
- Naproxen EP Impurity I (CAS 23981-47-7)
- methyl 4-{6-[(oxan-4-yl)amino]imidazo[1,2-b]pyridazin-3-yl}benzoate (CAS 928335-94-8)
- (E)-3-(2-(Naphthalen-2-ylmethyl)phenyl)acrylic acid (CAS 244103-25-1)
- 1H-imidazo[4,5-c]pyridine-4-carbonitrile (CAS 1078168-19-0)
- 2-(prop-2-en-1-ylamino)-1,3-thiazole-5-carboxylic acid (CAS 1384798-69-9)
- Allyl sorbate (CAS 7493-75-6)
- 2-(3-Methoxypropoxy)-N-methyl-1-propanamine (CAS 883531-44-0)
- Lixisenatide (CAS 320367-13-3)
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