2-(3,5-Bis(trifluoromethyl)phenyl)quinoline-8-carboxamide CAS 655222-65-4
| CAS No. | 655222-65-4 |
| Molecular Formula | C18H10F6N2O |
| Molecular Weight | 384.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(3,5-Bis(trifluoromethyl)phenyl)quinoline-8-carboxamide (CAS 655222-65-4), molecular formula C18H10F6N2O and molecular weight 384.28 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(3,5-Bis(trifluoromethyl)phenyl)quinoline-8-carboxamide (C18H10F6N2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 2-(3,5-Bis(trifluoromethyl)phenyl)quinoline-8-carboxamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H10F6N2O |
| Molecular Weight | 384.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Bis Standards
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- 1-Oxo-1-((3-(trifluoromethyl)phenyl)amino)propan-2-yl 2-(methylthio)nicotinate (CAS 522641-19-6)
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- 4-Phenyl-5-{[3-(trifluoromethyl)phenyl]methanesulfonyl}-1,2,3-thiadiazole (CAS 338398-50-8)
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Recommended Standards
- 2-(2-(4-Chloro-2-methylphenoxy)acetyl)-N-(4-chlorophenyl)hydrazine-1-carbothioamide (CAS 893327-61-2)
- 2,4-Dichloro-N-(1,5,6-trimethyl-1H-benzo[d]imidazol-4-yl)benzenesulfonamide (CAS 338411-08-8)
- 2-(2-(2,4-Dichlorophenoxy)propanoyl)-N-phenylhydrazine-1-carbothioamide (CAS 356526-30-2)
- 2,5-Dichloro-N-(1,5,6-trimethyl-1H-benzo[d]imidazol-4-yl)benzenesulfonamide (CAS 338410-94-9)
- 2-Trifluoromethylsulfanylmethylpiperidine (CAS 1208080-51-6)
- 2-(2-Cyano-3-fluorophenyl)-2-(4-fluorophenyl)pentanedinitrile (CAS 400076-78-0)
- 2-(Adamantan-1-yl)-4,7-dimethyl-1H-indole-3-carbaldehyde (CAS 891721-13-4)
- 2-Acetyl-1-methylpyrrole (CAS 932-16-1)
- 3-({1-[3-(4,5-Dihydro-1H-imidazol-2-ylamino)-propyl]-1H-indazole-4-carbonyl}-amino)-2-(2,6-dimethyl-4-oxazol-2-yl-benzenesulfonylamino)-propionic acid (CAS 1231024-63-7)
- 4-Azidopiperidine hydrochloride (CAS 852030-95-6)
- ((2R,3S,4S,5R)-3,4-Dihydroxytetrahydrofuran-2,5-diyl)bis(methylene) bis(dihydrogen phosphate) (CAS 671-08-9)
- Fmoc-Val-Cl (CAS 103321-53-5)
- 3-Chloro-2,6-difluoropyridine hydrate (CAS 1881331-11-8)
- Prolactin-Releasing Peptide (1-31) (human) (CAS 215510-22-8)
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