Minocycline EP Impurity B HCl CAS 6625-20-3
| CAS No. | 6625-20-3 |
| Molecular Formula | C21H22N2O7 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Minocycline EP Impurity B HCl (CAS 6625-20-3, C21H22N2O7HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Minocycline EP Impurity B HCl (C21H22N2O7HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Minocycline EP Impurity B HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H22N2O7 HCl |
| Molecular Weight | 450.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >80% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Minocycline Standards
- Minocycline Impurity N1 (CAS 10118-89-5)
- Minocycline (CAS 10118-90-8)
- Minocycline EP Impurity F (CAS 1075240-33-3)
- Minocycline Hydrochloride Dihydrate (CAS 128420-71-3)
- Minocycline EP Impurity H (CAS 1346598-44-4)
- Minocycline Hydrochloride (CAS 13614-98-7)
- Minocycline Impurity 26 (CAS 149934-16-7)
- Minocycline impurity 73 (CAS 156263-28-4)
Recommended Standards
- Sodium Valproate Impurity 18 (CAS 542-05-2)
- Azelastine impurity 57 (CAS CATO-C4X-139657)
- Eravacycline impurity 30 (CAS CATO-C4X-293830)
- 2-(4-Chlorophenyl)butanoyl Chloride (CAS 51631-64-2)
- (S)-Methyl 4-methyl-2,5-dihydro-1H-pyrrole-2-carboxylate (CAS 709610-26-4)
- 4-(1,3-Dioxaindan-5-ylmethylidene)-2-tert-butyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid (CAS 647036-25-7)
- 2-Hydrazineyl-2-methylpropan-1-ol dihydrochloride (CAS 2332831-26-0)
- 1,3-Dihydroisobenzofuran-5-carbonitrile (CAS 1027823-65-9)
- Bromhexine impurity 65 (CAS CATO-C4X-106065)
- Hexapeptide-9 (CAS 885024-94-2)
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