Vonoprazan Impurity 143 CAS 66715-65-9
| CAS No. | 66715-65-9 |
| Molecular Formula | C5H4ClNO2S |
| Molecular Weight | 177.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Vonoprazan Impurity 143 (CAS 66715-65-9), a pharmacopoeial impurity reference standard (molecular formula C5H4ClNO2S, MW 177.61 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C5H4ClNO2S, Vonoprazan Impurity 143 contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 177.61 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4ClNO2S |
| Molecular Weight | 177.61 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Impurity 16 (CAS 16133-25-8)
- Vonoprazan Impurity 192(Mixture of Z and E Isomers) (CAS CATO-C4X-1020192)
- Vonoprazan Impurity 200 (CAS CATO-C4X-1020200)
- Vonoprazan Impurity 216 (CAS 1428932-17-5)
- Vonoprazan Impuirty 86 (CAS 5402-21-1)
- Vonoprazan Impurity 289 (CAS CATO-C4X-1020289)
- Vonoprazan Impurity 112 (CAS 881673-95-6)
- Vonoprazan Impurity 188 (CAS 111480-82-1)
Recommended Standards
- 39060-31-6 5-Chlorbenzofurazan-3-oxide 6-chlorobenzo[c][1,2,5]oxadiazole 1-oxide (CAS 39060-31-6)
- Methyl 5-Chlorothiazole-2-carboxylate (CAS 98136-57-3)
- Pyridine-4-sulfonyl Chloride (CAS 134479-04-2)
- Methyl 2-chloro-1,3-thiazole-4-carboxylate (CAS 850429-61-7)
- Promestriene Impurity 5 (CAS CATO-C4X-22055)
- Minoxidil Impurity 41 (CAS CATO-C4X-170041)
- Semaglutide impurity 39 (CAS CATO-C4X-222639)
- n-(3-Hydroxyphenyl)thiophene-2-carboxamide (CAS 307525-91-3)
- 4-(Benzyloxy)-2-methoxybenzoic acid (CAS 85607-79-0)
- 2-Methylquinoline-4-carbaldehyde (CAS 6760-22-1)
- Methyl 2-(3-aminoazetidin-1-yl)propanoate (CAS 1478439-63-2)
- Ophiobolin C (CAS 19022-51-6)
- (3,4-Dichlorophenyl)(3-fluorophenyl)methanol (CAS 844683-63-2)
- Lixisenatide (CAS 320367-13-3)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com