Vonoprazan Impurity 16 CAS 16133-25-8
| CAS No. | 16133-25-8 |
| Molecular Formula | C5H4ClNO2S |
| Molecular Weight | 177.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Vonoprazan Impurity 16.
Vonoprazan Impurity 16 (CAS 16133-25-8) is a certified pharmaceutical impurity reference standard with the molecular formula C5H4ClNO2S and a molecular weight of 177.61 g/mol.
The molecular framework of Vonoprazan Impurity 16 (C5H4ClNO2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4ClNO2S |
| Molecular Weight | 177.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Impurity 143 (CAS 66715-65-9)
- Vonoprazan Impurity 192(Mixture of Z and E Isomers) (CAS CATO-C4X-1020192)
- Vonoprazan Impurity 200 (CAS CATO-C4X-1020200)
- Vonoprazan Impurity 216 (CAS 1428932-17-5)
- Vonoprazan Impuirty 86 (CAS 5402-21-1)
- Vonoprazan Impurity 289 (CAS CATO-C4X-1020289)
- Vonoprazan Impurity 112 (CAS 881673-95-6)
- Vonoprazan Impurity 188 (CAS 111480-82-1)
Recommended Standards
- Pyridine-4-sulfonyl Chloride (CAS 134479-04-2)
- 39060-31-6 5-Chlorbenzofurazan-3-oxide 6-chlorobenzo[c][1,2,5]oxadiazole 1-oxide (CAS 39060-31-6)
- Acetazolamide EP Impurity A (CAS 60320-32-3)
- Methyl 5-Chlorothiazole-2-carboxylate (CAS 98136-57-3)
- Bupropion Impurity 56 (CAS 80478-43-9)
- Norfloxacin EP Impurity E(Hydrochloride) (CAS 75001-78-4)
- Oseltamivir Impurity 44 (CAS 2413185-87-0)
- 1H,1H,7H-Perfluoroheptan-1-ol (CAS 335-99-9)
- 1H-4,7-Methanobenzo[d]imidazole (CAS 210-26-4)
- Ethyl 6-methoxy-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylate (CAS 628294-72-4)
- Elobixibat Impurity 31 (CAS CATO-C4X-283831)
- n-Cycloheptyl-1-methyl-1h-pyrazol-4-amine (CAS 1153977-58-2)
- 1-(2-Chlorophenyl)-1H-pyrazole (CAS 917508-36-2)
- Semaglutide impurity 80 (CAS CATO-C4X-222680)
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