Triclosan Impurity 5 CAS 67028-17-5
| CAS No. | 67028-17-5 |
| Molecular Formula | C12H5Cl3O2 |
| Molecular Weight | 287.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Triclosan Impurity 5 (C12H5Cl3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Triclosan Impurity 5 (CAS 67028-17-5), a pharmacopoeial impurity reference standard (molecular formula C12H5Cl3O2, MW 287.53 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Triclosan Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H5Cl3O2 |
| Molecular Weight | 287.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
Related Triclosan Standards
- Triclosan (CAS 3380-34-5)
- Triclosan-d3 (2,4-dichlorophenoxy-d3) (CAS 1020719-98-5)
- Triclosan-13C6 (CAS CATO-CCHM704075)
- Triclosan Methyl Ether (CAS 4640-01-1)
- Triclosan Impurity 4 (CAS 546127-65-5)
- Triclosan methyl D3 (methoxy D3) (CAS 1020720-00-6)
- Triclosan Impurity 3 (CAS 63709-57-9)
- Triclosan Impurity 7 (CAS 134479-47-3)
Recommended Standards
- 6-chloro-3-iodo-pyrazolo[1,5-a]pyrimidine (CAS 2306264-38-8)
- 3-[(4-Bromophenyl)methyl]-5-(chloromethyl)-1,2,4-oxadiazole (CAS 1094255-98-7)
- 5-Bromo-4-fluoro-2-methylbenzene-1-sulfonyl chloride (CAS 874804-12-3)
- 5-[(4-bromophenyl)methyl]-3-(chloromethyl)-1,2,4-oxadiazole (CAS 1152504-39-6)
- Ticagrelor Impurity 158 (CAS 1402150-27-9)
- Baloxavir Impurity 152 (CAS CATO-C4X-2108152)
- Vericiguat Impurity 78 (CAS CATO-C4X-289678)
- (1-Ethyl-1H-pyrazol-4-yl)acetonitrile (CAS 1238437-27-8)
- 9-([1,1'-Biphenyl]-4-yl)-2-chloro-9H-carbazole (CAS 1259388-62-9)
- 5-(5-Methylfuran-2-yl)pyrazin-2-ol (CAS 1803583-75-6)
- 5-Chloro-2-methoxynicotinaldehyde (CAS 103058-88-4)
- Carbamic acid, N-(3-methylenecyclobutyl)-N-(phenylmethyl)-, phenylmethyl ester (CAS 1956355-09-1)
- N-butyl-N-methylpiperidin-4-amine dihydrochloride (CAS 1220035-47-1)
- Semaglutide Impurity 158 (x TFA Salt) (CAS CATO-C4X-2226158)
Why CATO?
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