Tizanidine Impurity 67 CAS 67357-56-6
| CAS No. | 67357-56-6 |
| Molecular Formula | C10H9ClN2O2 |
| Molecular Weight | 224.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tizanidine Impurity 67 (CAS 67357-56-6, C10H9ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tizanidine Impurity 67 (C10H9ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 224.64 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Tizanidine Impurity 67 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H9ClN2O2 |
| Molecular Weight | 224.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tizanidine Standards
- Tizanidine Impurity 65 (CAS 67357-54-4)
- Tizanidine Impurity 66 (CAS 67357-53-3)
- Tizanidine Guanidine Impurity (CAS 125292-37-7)
- Tizanidine EP Impurity A (CAS 51322-69-1)
- Tizanidine impurity 29 (CAS CATO-C4X-144529)
- Tizanidine impurity 20 (CAS CATO-C4X-144520)
- Tizanidine impurity 26 (CAS CATO-C4X-144526)
- Tizanidine Hydrochloride EP Impurity G (CAS 51322-80-6)
Recommended Standards
- Bosutinib Impurity N1 (CAS 879644-03-8)
- 6-Chloro-3-(oxolan-2-yl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1152577-81-5)
- Flumazenil Impurity 9 (CAS 5973-29-5)
- 2-Chloro-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)pyridine (CAS 1184913-59-4)
- Bosentan Impurity 14 (CAS 1355251-10-3)
- Tucatinib Impurity 39 (CAS CATO-C4X-260539)
- Vinorelbine Impurity 23 (CAS CATO-C4X-264223)
- Ethyl 5-(4-biphenyl)-5-oxovalerate (CAS 138247-17-3)
- 4-Cyclohexyl-3,4-dihydroisoquinolin-1(2H)-one (CAS 55150-60-2)
- 5-Fluoro-2-((4-methoxyphenyl)ethynyl)benzaldehyde (CAS 1042369-35-6)
- tert-Butyl (S)-3-(4-methylbenzyl)piperazine-1-carboxylate (CAS 1240589-44-9)
- 5-Chloro-2-(1H-pyrazol-5-yl)aniline (CAS 15463-66-8)
- 2,6-Dibromo-1-iodo-4-(trifluoromethyl)benzene (CAS 1428234-52-9)
- Tirzepatide (CAS 2023788-19-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com