Rivaroxaban Impurity 101 CAS 67482-49-9
| CAS No. | 67482-49-9 |
| Molecular Formula | C5H2Cl2OS |
| Molecular Weight | 181.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Rivaroxaban Impurity 101 (CAS 67482-49-9) is a certified pharmaceutical impurity reference standard with the molecular formula C5H2Cl2OS and a molecular weight of 181.04 g/mol.
Structurally, Rivaroxaban Impurity 101 (C5H2Cl2OS) contains sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 181.04 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H2Cl2OS |
| Molecular Weight | 181.04 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 74 (CAS 113471-08-2)
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- Rivaroxaban Impurity 84 (CAS 2524-67-6)
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- Rivaroxaban Impurity 103 (CAS 35475-03-7)
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- Rivaroxaban Impurity 137 (CAS 3140-73-6)
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