2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-[4-(trifluoromethoxy)phenyl]acetonitrile CAS 677749-56-3
| CAS No. | 677749-56-3 |
| Molecular Formula | C19H8F9N3O |
| Molecular Weight | 465.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-[4-(trifluoromethoxy)phenyl]acetonitrile (CAS 677749-56-3) is a high-purity analytical reference standard with the molecular formula C19H8F9N3O and a molecular weight of 465.27 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-[4-(trifluoromethoxy)phenyl]acetonitrile is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 465.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-[4-(trifluoromethoxy)phenyl]acetonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H8F9N3O |
| Molecular Weight | 465.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Bis Standards
- N1-[2-(trifluoromethyl)phenyl]-2-({5-[(4,5-dichloro-1H-imidazol-1-yl)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}thio)acetamide (CAS 650592-14-6)
- 1,2-Bis(trifluoromethyl)-4,5-diiodobenzene (CAS 1805519-29-2)
- 2,2'-(2,5-Bis(trifluoromethyl)-1,4-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 1073339-16-8)
- 5-Oxo-2-(trifluoromethyl)-N-{[3-(trifluoromethyl)phenyl]methyl}-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 241127-06-0)
- 3-Phenyl-6-(trifluoromethyl)-N-(3-(trifluoromethyl)phenyl)thieno[3,2-b]pyridine-2-carboxamide (CAS 478260-60-5)
- 1-(3-(Trifluoromethyl)phenoxy)-3-(triphenyl-l5-phosphanylidene)propan-2-one (CAS 73718-90-8)
- 1-((3,5-Bis(trifluoromethyl)phenyl)sulfonyl)-4-(2,6-dimethylphenyl)piperazine (CAS 873679-81-3)
- 2-(5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl)-N-(4-chlorophenyl)-2-methylhydrazine-1-carboxamide (CAS 320417-46-7)
Recommended Standards
- 1-(5-(Benzyloxy)-2,4-dichlorophenyl)-5-(3-(trifluoromethyl)phenyl)-1H-tetrazole (CAS 338961-48-1)
- Ciprofibrate-O--Glucuronide (CAS 102623-15-4)
- 1-(3-(3,4-Dichlorophenyl)imidazo[1,2-a]pyridin-8-yl)-3-(3-(trifluoromethyl)phenyl)urea (CAS 338415-26-2)
- Methyl (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-iodobutanoate (CAS 1323995-10-3)
- N1,N1,N1,N6,N6,N6-Hexamethylhexane-1,6-diaminium chloride dihydrate (CAS 16986-49-5)
- 2-(3-Methylpiperidin-1-yl)-N-(naphthalen-1-yl)acetamide (CAS 653584-73-7)
- 3-aminopropane-1-sulfinic acid (CAS 25346-09-2)
- 1-Bromo-3-chloro-5-fluorobenzene-d3 (CAS 1219805-00-1)
- Olivetol 4-Bromo (CAS 78463-35-1)
- 5-Bromo-2-((2-hydroxybenzyl)amino)benzonitrile (CAS 255865-20-4)
- Terephthalylidene Dicamphor Sulfonie Acid (CAS 90457-82-2)
- (2-(Trifluoromethyl)phenyl)methanethiol (CAS 26039-98-5)
- 4-Bromo-2-(chloromethyl)-1-fluorobenzene (CAS 1020992-68-0)
- Semaglutide impurity 50 (CAS 2773558-66-8)
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