4-Chloro-6-methyl-2-phenyl-5-(3-(trifluoromethyl)phenoxy)pyrimidine CAS 680217-69-0
| CAS No. | 680217-69-0 |
| Molecular Formula | C18H12ClF3N2O |
| Molecular Weight | 364.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Chloro-6-methyl-2-phenyl-5-(3-(trifluoromethyl)phenoxy)pyrimidine is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-Chloro-6-methyl-2-phenyl-5-(3-(trifluoromethyl)phenoxy)pyrimidine (CAS 680217-69-0), a certified reference material (molecular formula C18H12ClF3N2O, MW 364.75 g/mol) for analytical method development and quality control.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 4-Chloro-6-methyl-2-phenyl-5-(3-(trifluoromethyl)phenoxy)pyrimidine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 364.75 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H12ClF3N2O |
| Molecular Weight | 364.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- (3Z)-4-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}but-3-en-2-one (CAS 1164455-16-6)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-6-methyl-N-phenylpyrimidin-4-amine (CAS 1357147-49-9)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(1E)-(methoxyamino)methylidene]piperidine-4-carboxamide (CAS 303144-37-8)
- 2-Chloro-N-[5-(dimethylamino)-2-nitrophenyl]-5-nitrobenzamide (CAS 1079264-82-6)
- N-[5-Chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[1-(hydroxyimino)ethyl]-5-thiazolecarboxamide (CAS 1095823-58-7)
- N-(6-Chloro-4-(trifluoromethyl)pyridin-2-yl)-4,N-dimethylbenzenesulfonamide (CAS 1311280-33-7)
- [({[(2-chloro-3-phenylprop-2-enylidene)amino]oxy}carbonyl)amino](2,6-difluorophenyl)methanone (CAS 680580-31-8)
- 1-(2-Chloro-6-fluorobenzyl)-3-(4-fluorobenzyl)imidazolidine-2,4,5-trione (CAS 341966-54-9)
Recommended Standards
- 1-Acetyl-N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carbohydrazide (CAS 439094-42-5)
- N-(2-chlorobenzyl)-2-(pyridin-2-yl)-6-(trifluoromethyl)pyrimidin-4-amine (CAS 338754-48-6)
- N-(4-Chlorobenzyl)-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinamine (CAS 338754-27-1)
- 1-(4-Chlorophenyl)-2,2,2-trifluoroethyl 4-methylbenzenesulfonate (CAS 907175-73-9)
- 7-Chloroquinolin-6-ol (CAS 1261561-19-6)
- Benzyl (R)-(3-hydroxy-1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate (CAS 1092473-80-7)
- N-Allyl-2-methoxyacetamide (CAS 486393-59-3)
- (7-Methoxy-3,4-dihydro-2H-1-benzopyran-2-yl)methanol (CAS 180716-14-7)
- 2,3,6,7,10,11-Hexahydro-1H,5H-cyclopenta[4,5]pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-12(9H)-one (CAS 41175-45-5)
- n-(1-(Furan-2-yl)ethyl)-1-methyl-1h-pyrazol-3-amine (CAS 1182751-05-8)
- Methyl 3-amino-5-methoxybenzoate hydrochloride (CAS 1956317-99-9)
- Bis(cyclopentadiene)chromium(II) (CAS 1271-24-5)
- 8-Geranyloxypsoralen (CAS 7437-55-0)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
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