2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-6-methyl-N-phenylpyrimidin-4-amine CAS 1357147-49-9
| CAS No. | 1357147-49-9 |
| Molecular Formula | C17H12ClF3N4 |
| Molecular Weight | 364.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-6-methyl-N-phenylpyrimidin-4-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-6-methyl-N-phenylpyrimidin-4-amine (CAS 1357147-49-9) is a high-purity analytical reference standard with the molecular formula C17H12ClF3N4 and a molecular weight of 364.75 g/mol.
The molecular framework of 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-6-methyl-N-phenylpyrimidin-4-amine (C17H12ClF3N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H12ClF3N4 |
| Molecular Weight | 364.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- (3Z)-4-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}but-3-en-2-one (CAS 1164455-16-6)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(1E)-(methoxyamino)methylidene]piperidine-4-carboxamide (CAS 303144-37-8)
- 4-Chloro-6-methyl-2-phenyl-5-(3-(trifluoromethyl)phenoxy)pyrimidine (CAS 680217-69-0)
- 2-Chloro-N-[5-(dimethylamino)-2-nitrophenyl]-5-nitrobenzamide (CAS 1079264-82-6)
- N-[5-Chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[1-(hydroxyimino)ethyl]-5-thiazolecarboxamide (CAS 1095823-58-7)
- N-(6-Chloro-4-(trifluoromethyl)pyridin-2-yl)-4,N-dimethylbenzenesulfonamide (CAS 1311280-33-7)
- [({[(2-chloro-3-phenylprop-2-enylidene)amino]oxy}carbonyl)amino](2,6-difluorophenyl)methanone (CAS 680580-31-8)
- 1-(2-Chloro-6-fluorobenzyl)-3-(4-fluorobenzyl)imidazolidine-2,4,5-trione (CAS 341966-54-9)
Recommended Standards
- 1-Acetyl-N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carbohydrazide (CAS 439094-42-5)
- ethyl 4-[(2-chloro-3-pyridyl)oxy]-5,8-difluoroquinoline-3-carboxylate (CAS 245073-04-5)
- 3-(4-Chlorobenzenesulfonyl)-5-(trifluoromethyl)pyridine-2-carboxamide (CAS 338406-81-8)
- N-(2-chlorobenzyl)-2-(pyridin-2-yl)-6-(trifluoromethyl)pyrimidin-4-amine (CAS 338754-48-6)
- 2,6-Dichloro-n'-hydroxybenzene-1-carboximidamide (CAS 23505-21-7)
- 4-(Bicyclo[1.1.1]Pentan-1-ylthio)aniline (CAS 1935223-20-3)
- N-((1H-Imidazol-4-yl)methyl)methanesulfonamide (CAS 279679-98-0)
- 6-Bromo-4-iodonicotinonitrile (CAS 1061357-87-6)
- n-(Prop-2-yn-1-yl)tetrahydrothiophen-3-amine (CAS 1019581-95-3)
- 1,1,2,2,3,3,4,4,4-Nonafluoro-N,N-bis(2-hydroxyethyl)butane-1-sulfonamide (CAS 34455-00-0)
- 1-[4-(Trifluoromethyl)phenyl]-2-hexanone (CAS 477202-15-6)
- Eltrombopag impurity 139 (CAS CATO-C4X-1198139)
- 4-(1-Aminoethyl)thiazol-2-amine (CAS 1344258-30-5)
- D-Tyr1-Tirzepatide (CAS CATO-CPTD788928)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com