Sulindac Impurity 1 CAS 68299-97-8
| CAS No. | 68299-97-8 |
| Molecular Formula | C22H21FO3S |
| Molecular Weight | 384.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Sulindac Impurity 1 (C22H21FO3S) is characterized by a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Sulindac Impurity 1 (CAS 68299-97-8) is a certified pharmaceutical impurity reference standard with the molecular formula C22H21FO3S and a molecular weight of 384.46 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sulindac Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H21FO3S |
| Molecular Weight | 384.46 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Sulindac Standards
- (R)-Sulindac Methyl Ester (CAS 929081-61-8)
- Sulindac Sulfone-d7 (CAS CATO-C4X-293019)
- Sulindac EP Impurity B-d3 (CAS 250608-67-4)
- Sulindac Impurity N94 (CAS CATO-CP155194)
- Sulindac Sulfone (CAS 59864-04-9)
- Sulindac EP Impurity B (CAS 59973-80-7)
- Sulindac EP Impurity D (CAS 134439-52-4)
- Sulindac Sulfide Methyl Ester (CAS 106647-49-8)
Recommended Standards
- 2,5,8,11,14,17,20,23-Octaoxapentacosan-25-ol (CAS 25990-96-9)
- N1-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(1-methyl-1H-pyrrol-2-yl)ethyl)-N2-(2-methoxyethyl)oxalamide (CAS 1049454-03-6)
- N-(4-Ethoxyphenyl)-2-((4-ethyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 573948-03-5)
- (R)-N-(2-Benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide (CAS 105024-93-9)
- Lumateperone Impurity 31 (CAS 313369-33-4)
- Bromperidol EP Impurity A HCl (CAS 4021-57-2)
- Ergosterol Impurity 6 (CAS 105620-21-1)
- 4,5-Dimethoxyisoindolin-1-one (CAS 954239-37-3)
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- Benzyl Azetidine-3-carboxylate Trifluoroacetate (CAS 2006278-23-3)
- 1-(4-Ethynylphenyl)-2-methyl-1H-imidazole (CAS 1824572-21-5)
- Tirzepatide Impurity 26 X TFA Salt (CAS CATO-C4X-324026)
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