Isavuconazole Impurity 61 CAS 683274-86-4
| CAS No. | 683274-86-4 |
| Molecular Formula | C9H6BrNO |
| Molecular Weight | 224.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Isavuconazole Impurity 61 (CAS 683274-86-4), a pharmacopoeial impurity reference standard (molecular formula C9H6BrNO, MW 224.05 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Isavuconazole Impurity 61 (C9H6BrNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 224.05 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H6BrNO |
| Molecular Weight | 224.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Isavuconazole Standards
- Isavuconazole Impurity 31 (CAS 20099-89-2)
- Isavuconazole Impurity 224 (CAS CATO-C4X-1236224)
- Isavuconazole Impurity N16 (CAS 2491-38-5)
- Isavuconazole Impurity 106 (CAS 150803-17-1)
- Isavuconazole Impurity 112 (CAS CATO-C4X-1236112)
- Isavuconazole Impurity 181 (CAS CATO-C4X-1236181)
- Isavuconazole Impurity 66 (CAS 258513-41-6)
- Isavuconazole impurity 214 (CAS CATO-C4X-1236214)
Recommended Standards
- (6-(3-(Dimethylamino)propoxy)pyridin-3-yl)boronic acid (CAS 1003043-49-9)
- Bedaquiline impurity 42 (CAS 90279-39-3)
- 2-Bromo-5-(1H-pyrrol-1-yl)pyrazine (CAS 1027512-24-8)
- Bedaquiline impurity 41 (CAS 860720-24-7)
- Etizolam Impurity 23 (CAS CATO-C4X-350923)
- Chlorphenamine Impurity 25 (CAS 122376-68-5)
- Niraparib Impurity 45 (CAS 1476776-97-2)
- 4-[4-(Benzyloxy)phenyl]-1-[(4-chlorophenyl)methyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 860786-56-7)
- Tert-butyl 4-(2-(4-chlorophenyl)-2-oxoethyl)piperazine-1-carboxylate (CAS 1146080-70-7)
- Serratamic Acid (CAS 541-81-1)
- 2-(Trifluoromethyl)-7,8-dihydroquinolin-6(5H)-one (CAS 944895-70-9)
- Methyl-2,3-O-isopropylidene-a-D-mannopyranoside (CAS 63167-69-1)
- 5-Bromo-2-ethylthiophene-3-carbaldehyde (CAS 1150223-09-8)
- [Nva12]-Tirzepatide (CAS CATO-C4X-324042)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com