Isavuconazole Impurity N16 CAS 2491-38-5
| CAS No. | 2491-38-5 |
| Molecular Formula | C8H7BrO2 |
| Molecular Weight | 215.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Isavuconazole Impurity N16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Isavuconazole Impurity N16 (CAS 2491-38-5) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7BrO2 and a molecular weight of 215.05 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system, Isavuconazole Impurity N16 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 215.05 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H7BrO2 |
| Molecular Weight | 215.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
Related Isavuconazole Standards
- Isavuconazole Impurity 181 (CAS CATO-C4X-1236181)
- Isavuconazole Impurity N12 (CAS 2732924-98-8)
- Isavuconazole Impurity 31 (CAS 20099-89-2)
- Isavuconazole Impurity 61 (CAS 683274-86-4)
- Isavuconazole Impurity 224 (CAS CATO-C4X-1236224)
- Isavuconazole impurity 73 (CAS CATO-C4X-1236173)
- Isavuconazole Impurity 106 (CAS 150803-17-1)
- Isavuconazole Impurity 112 (CAS CATO-C4X-1236112)
Recommended Standards
- Iloperidone Impurity 8 (CAS 1209459-88-0)
- 1-bromo-6-fluoro-2,3-dihydro-1H-indene (CAS 1188147-00-3)
- Vortioxetine Impurity 100 (CAS 17576-86-2)
- 1-Bromo-4-fluoro-2,3-dihydro-1h-indene (CAS 1188171-96-1)
- Apixaban Impurity 25 (CAS CATO-C4X-108825)
- Pyrazoloquinolone Impurity 3 (CAS CATO-C4X-23893)
- Sulbactam Impurity 39 (CAS 69388-83-6)
- 1-Benzyl-6-hydroxy-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydropyrimidine-4-carboxamide (CAS 338412-62-7)
- N-tert-Butyl-3-hydroxy-5-nitrobenzamide (CAS 1881295-27-7)
- Dotinurad Impurity 232 (CAS CATO-C4X-2494232)
- 1-{4-methoxypyrrolo[2,1-f][1,2,4]triazin-6-yl}propan-2-amine (CAS 1555667-17-8)
- Hercoflex® 900 (CAS 68186-30-1)
- 3-Bromo-4-[(4-methylpiperazin-1-yl)methyl]aniline (CAS 859027-13-7)
- Insulin Degludec Impurity 14 (CAS CATO-C4X-215714)
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