Dabrafenib Impurity 8 CAS 686258-75-3
| CAS No. | 686258-75-3 |
| Molecular Formula | C6H4F2O3S |
| Molecular Weight | 194.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dabrafenib Impurity 8 (CAS 686258-75-3, C6H4F2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dabrafenib Impurity 8 (C6H4F2O3S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dabrafenib Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H4F2O3S |
| Molecular Weight | 194.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Dabrafenib Standards
- Dabrafenib Impurity 31 (CAS CATO-C4X-303331)
- Dabrafenib Impurity 33 (CAS CATO-C4X-303333)
- Dabrafenib Impurity 3 (CAS CATO-C4X-30333)
- Dabrafenib Impurity 28 (CAS CATO-C4X-303328)
- Dabrafenib Impurity 25 (CAS 1353575-68-4)
- Dabrafenib Impurity 29 (CAS CATO-C4X-303329)
- Dabrafenib Impurity 35 (CAS CATO-C4X-303335)
- Dabrafenib Impurity 39 (CAS CATO-C4X-303339)
Recommended Standards
- Paliperidone Impurity 129 (CAS 46020-63-7)
- (2-Oxypropyl)phosphonate diethyl ester (CAS 1067-71-6)
- Methyl 8-fluoroimidazo[1,2-a]pyridine-7-carboxylate (CAS 628691-97-4)
- 5-(4-Fluoro-3-methoxyphenyl)-2H-tetrazole (CAS 1092657-05-0)
- Linezolid Impurity 90 (CAS CATO-C4X-107390)
- Tadalafil Impurity 24 (CAS 951661-81-7)
- Ilaprazole Impurity 31 (CAS 2285346-38-3)
- (S)-1-(9H-Fluoren-9-yl)-5-isobutyl-3,6,9,12-tetraoxo-2-oxa-4,7,10,13-tetraazapentadecan-15-oic acid (CAS 169168-88-1)
- Tert-butyl (6-bromoisoquinolin-3-yl)carbamate (CAS 944805-36-1)
- 5-Amino-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 1183402-93-8)
- 1-propyne magnesium bromide solution (CAS 16466-97-0)
- Ethyl 2-(3-bromo-1H-indazol-5-yl)acetate (CAS 2114116-78-6)
- 2-Chloro-5-(difluoromethyl)-3-fluoro-6-methoxypyridine (CAS 1805982-94-8)
- Semaglutide Impurity 143 (CAS CATO-C4X-2226143)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com