Dabrafenib Impurity 33 CAS CATO-C4X-303333
| CAS No. | CATO-C4X-303333 |
| Molecular Formula | C10H8Cl2N4 |
| Molecular Weight | 255.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 255.10 g/mol gives Dabrafenib Impurity 33 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Dabrafenib Impurity 33 (CAS CATO-C4X-303333, C10H8Cl2N4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dabrafenib Impurity 33 (C10H8Cl2N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Dabrafenib Impurity 33 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H8Cl2N4 |
| Molecular Weight | 255.10 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Dabrafenib Standards
- Dabrafenib Impurity 3 (CAS CATO-C4X-30333)
- Dabrafenib Impurity 28 (CAS CATO-C4X-303328)
- Dabrafenib Impurity 25 (CAS 1353575-68-4)
- Dabrafenib Impurity 31 (CAS CATO-C4X-303331)
- Dabrafenib Impurity 29 (CAS CATO-C4X-303329)
- Dabrafenib Impurity 35 (CAS CATO-C4X-303335)
- Dabrafenib Impurity 8 (CAS 686258-75-3)
- Dabrafenib Impurity 39 (CAS CATO-C4X-303339)
Recommended Standards
- Ozenoxacin Impurity 70 (CAS CATO-C4X-279670)
- 2-Hydroxy-4,4＇-dichlorodiphenyl Ether (CAS 3380-30-1)
- Oxiconazole USP Related Compound C(Free Form) (CAS 46503-52-0)
- Diclomezine (CAS 62865-36-5)
- HISTIDINE Impurity 6 (CAS 1932060-69-9)
- Zolmitriptan Impurity 38 (CAS CATO-C4X-135138)
- Rebamipide Impurity 48 (CAS CATO-C4X-152348)
- 1-((1-Ethyl-1H-pyrazol-4-yl)methyl)-4-methyl-1H-pyrazol-5-amine (CAS 1415719-61-7)
- 2-(2,3-Dimethylimidazo[1,2-b][1,2,4]triazin-6-yl)ethanamine (CAS 1092292-64-2)
- Methyl 2,4,6-trimethylnicotinate (CAS 2114473-77-5)
- 4-Methyl-3,5-di-m-tolyl-1H-pyrazole (CAS 1159988-71-2)
- 3-Methoxyisoxazole-5-carboxamide (CAS 16880-10-7)
- 2-(3-Oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)-n-(4-propoxyphenyl)acetamide (CAS 1008659-07-1)
- Semaglutide impurity 75 (CAS CATO-C4X-222675)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com