Pioglitazone Impurity 2 CAS 69088-97-7
| CAS No. | 69088-97-7 |
| Molecular Formula | C8H8O4S |
| Molecular Weight | 200.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Pioglitazone Impurity 2 (C8H8O4S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Pioglitazone Impurity 2 (CAS 69088-97-7) is a certified pharmaceutical impurity reference standard with the molecular formula C8H8O4S and a molecular weight of 200.21 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8O4S |
| Molecular Weight | 200.21 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Sulfur Atoms | 1 |
Related Pioglitazone Standards
- Pioglitazone impurity 56 (CAS 1258625-43-2)
- Pioglitazone Impurity 24 (CAS 127676-18-0)
- Pioglitazone Impurity 8 (CAS 74772-78-4)
- Pioglitazone Impurity 15 (CAS 291536-42-0)
- Pioglitazone Impurity 19 (CAS 144809-26-7)
- Pioglitazone Impurity 20 (CAS 69603-36-7)
- Pioglitazone Impurity 14 (CAS 1526933-30-1)
- Pioglitazone Impurity 23 (CAS CATO-C4X-138323)
Recommended Standards
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- 2-(3-Fluorophenyl)-1-(4-fluorophenyl)ethan-1-one (CAS 370874-66-1)
- N-(2,2,2-Trifluoroethyl)thiophene-3-carboxamide (CAS 1207005-38-6)
- (3-(Aminomethyl)pyrrolidin-1-yl)(2,4-dichlorophenyl)methanone (CAS 1838414-73-5)
- 3,5-Dimethyl-1-(pentan-3-yl)-1h-pyrazol-4-amine (CAS 1248935-11-6)
- 1-[3-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-pyrrolidine-2,5-dione (CAS 2096997-21-4)
- Semaglutide impurity 33 (CAS CATO-C4X-222633)
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