Ticagrelor impurity 136 CAS 1932275-13-2
| CAS No. | 1932275-13-2 |
| Molecular Formula | C10H9F2NO |
| Molecular Weight | 197.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ticagrelor impurity 136 (CAS 1932275-13-2) is a certified pharmaceutical impurity reference standard with the molecular formula C10H9F2NO and a molecular weight of 197.18 g/mol.
The molecular framework of Ticagrelor impurity 136 (C10H9F2NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ticagrelor impurity 136 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9F2NO |
| Molecular Weight | 197.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ticagrelor Standards
- Ticagrelor Impurity 152 (CAS 1006376-62-0)
- Ticagrelor impurity 84（trans） (CAS 1006614-51-2)
- Ticagrelor Impurity 74 (CAS 220352-36-3)
- Ticagrelor Impurity 135 (CAS CATO-C4X-1093135)
- Ticagrelor Impurity 173 (CAS 1212376-05-0)
- Ticagrelor Impurity N40 (CAS 1006376-60-8)
- Ticagrelor Impurity 153 (CAS CATO-C4X-1093153)
- Ticagrelor Impurity 78 (CAS 1351990-36-7)
Recommended Standards
- Dichlorocyclohexylmethylsilane (CAS 5578-42-7)
- Azetidin-1-yl-(3,4-difluorophenyl)-methanone (CAS 863505-11-7)
- Azetidin-1-yl-(2,4-difluorophenyl)methanone (CAS 955885-22-0)
- 1-(3,5-Dimethyl-4-nitro-1h-pyrazol-1-yl)propan-2-one (CAS 1002651-00-4)
- Azithromycin EP Impurity C (CAS 620169-47-3)
- Lapatinib Impurity 17 (CAS 231278-05-0)
- Levocarnitine Impurity 43 (CAS 6538-82-5)
- Pyridostigmine Impurity 5 (CAS CATO-C4X-26305)
- N-(4-(1H-Pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide (CAS 1072906-02-5)
- 6-Chloro-1H-imidazo[4,5-c]pyridin-2-ol (CAS 7205-43-8)
- 2-{4-aminopyrrolo[2,1-f][1,2,4]triazin-2-yl}acetonitrile (CAS 2090156-72-0)
- 2-chloro-N-(4-methylphenyl)-2-phenylacetamide (CAS 10295-50-8)
- 9H-4,9'-Bicarbazole (CAS 1226810-17-8)
- Biotinyl-Neuropeptide W-23 (human) (CAS 1815618-09-7)
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