Edoxaban Impurity 33 CAS 349125-14-0
| CAS No. | 349125-14-0 |
| Molecular Formula | C12H8Cl2N4O2 |
| Molecular Weight | 311.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 311.12 g/mol gives Edoxaban Impurity 33 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Edoxaban Impurity 33 (CAS 349125-14-0) is a certified pharmaceutical impurity reference standard with the molecular formula C12H8Cl2N4O2 and a molecular weight of 311.12 g/mol.
The molecular framework of Edoxaban Impurity 33 (C12H8Cl2N4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8Cl2N4O2 |
| Molecular Weight | 311.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Edoxaban Standards
- Edoxaban Impurity 35 (CAS 480450-69-9)
- Edoxaban Impurity 85 (CAS 480451-97-6)
- Edoxaban Impurity 74 (CAS 1210348-21-2)
- Edoxaban Impurity N37 (CAS 365997-34-8)
- Edoxaban Impurity 86 (CAS CATO-C4X-106386)
- Edoxaban Impurity 8 (CAS CATO-C4X-10638)
- Edoxaban Impurity 32 (CAS 1461714-66-8)
- Edoxaban Impurity 47 (CAS 1210348-16-5)
Recommended Standards
- N1-(4,6-Dichloropyrimidin-5-yl)-N1-phenyloxalamide (CAS 59808-65-0)
- 1-(4-Bromophenyl)-N,N-dimethyl-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide (CAS 1000574-12-8)
- Clozapine Impurity 1 (CAS 69414-55-7)
- Methyl 1-((4-bromophenoxy)methyl)-1h-pyrazole-3-carboxylate (CAS 1001500-22-6)
- Posaconazole Impurity 66 (CAS 165115-83-3)
- Pomalidomide Impurity 22 (CAS 13139-52-1)
- Tolvaptan Impurity 38 (CAS 3951-89-1)
- 3,5-Dichloro-3-methylbenzophenone (CAS 951887-42-6)
- 2-Chlorophenyloxoacetyl chloride (CAS 1159373-66-6)
- 2-Amino-7-bromo-5-fluoroquinazoline (CAS 1379341-83-9)
- N,N-Dimethyl-1,2-cyclohexanediamine (CAS 61798-24-1)
- N-cyclopropyl-3-fluoro-2-methylbenzamide (CAS 1934600-56-2)
- Piperidin-1-yl(4-(piperidin-1-ylsulfonyl)piperazin-1-yl)methanone (CAS 825607-36-1)
- FMRF-Like Peptide from snail Helix aspersa (CAS 98495-35-3)
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