5-Chloro-3-hydroxyisobenzofuran-1(3H)-one CAS 70097-46-0
| CAS No. | 70097-46-0 |
| Molecular Formula | C8H5ClO3 |
| Molecular Weight | 184.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 5-Chloro-3-hydroxyisobenzofuran-1(3H)-one (CAS 70097-46-0), a certified reference material (molecular formula C8H5ClO3, MW 184.58 g/mol) for analytical method development and quality control.
5-Chloro-3-hydroxyisobenzofuran-1(3H)-one (C8H5ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 5-Chloro-3-hydroxyisobenzofuran-1(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClO3 |
| Molecular Weight | 184.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
Related Chloro Standards
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- 4-Chloro-3,7-dihydro-1H-pyrrolo[2,3-b]pyridine-2,6-dione (CAS 1190313-44-0)
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Recommended Standards
- 5-Chloro-2-methyl-7H-[1,2]oxazolo[2,3-a]pyrimidin-7-one (CAS 278614-92-9)
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- 5-Chloro-2-hydroxyisophthalaldehyde (CAS 32596-43-3)
- 5-Chlorobenzo[d][1,3]dioxole-4-carbaldehyde (CAS 249636-63-3)
- (3E)-3-[(4-methoxyphenyl)methylidene]pyrrolidin-2-one (CAS 154617-54-6)
- (4Z)-4-{[(4-chlorophenyl)amino]methylidene}-3-phenyl-4,5-dihydro-1,2-oxazol-5-one (CAS 477851-18-6)
- 1-Bromo-4-ethoxy-2-isopropylbenzene (CAS 2635937-91-4)
- (R)-3-Amino-3-(3-methoxy-5-(trifluoromethyl)phenyl)propan-1-ol (CAS 1336071-24-9)
- 1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde (CAS 144890-91-5)
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- 3-(Chloromethyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole (CAS 306936-06-1)
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