Roflumilast impurity 18 CAS 7051-34-5

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.7051-34-5
Molecular FormulaC4H7Br
Molecular Weight135.00 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Roflumilast impurity 18 CAS 7051-34-5 chemical structure

Description

The occurrence of Roflumilast impurity 18 is closely related to bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Roflumilast impurity 18 (CAS 7051-34-5), a pharmacopoeial impurity reference standard (molecular formula C4H7Br, MW 135.00 g/mol) used for the identification and quantification of trace impurities in APIs.

Roflumilast impurity 18 (C4H7Br) contains bromine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC4H7Br
Molecular Weight135.00 g/mol
Purity97%+
StorageStore at 2-8°C, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO
StabilityStable under recommended storage conditions
Degree of Unsaturation (DBE)1.0
CAS Registry Year (est.)1959
Halogen ContentBr-containing

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