Doxazosin EP Impurity B CAS 70918-74-0
| CAS No. | 70918-74-0 |
| Molecular Formula | C13H16N2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Doxazosin EP Impurity B (CAS 70918-74-0, C13H16N2O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Doxazosin EP Impurity B (C13H16N2O3HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 284.74 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Doxazosin EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H16N2O3 HCl |
| Molecular Weight | 284.74 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Doxazosin Standards
Recommended Standards
- Pramipexole Impurity 55 (CAS CATO-C4X-110755)
- Fruquintinib Impurity 11 (CAS CATO-C4X-303711)
- Palbociclib Impurity 114 (CAS 412348-27-7)
- Mefatinib Impurity 9 (CAS CATO-C4X-29929)
- 1,1'-(1H-Indole-1,6-diyl)diethanone (CAS 155703-10-9)
- Potassium bis(2-ethylhexyl) phosphate (CAS 4971-46-4)
- 4-Imino-1,3-dimethyl-1H-pyrazol-5(4H)-one (CAS 126230-42-0)
- 1-chloro-2-cyclopropoxybenzene (CAS 38380-89-1)
- 1-Methoxy-4-(1-propyn-1-yl)benzene (CAS 2749-94-2)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com