Estriol Impurity 27 CAS 7219-89-8

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.7219-89-8
Molecular FormulaC24H32O9
Molecular Weight464.51 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Estriol Impurity 27 CAS 7219-89-8 chemical structure

Description

Owing to a flavonoid core, a hydroxyl group, an ether linkage, Estriol Impurity 27 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 464.51 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

As a process- or degradation-related impurity, Estriol Impurity 27 (CAS 7219-89-8, C24H32O9) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC24H32O9
Molecular Weight464.51 g/mol
AppearancePale yellow to yellow crystalline powder
Purity≥95%
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1959

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