Atenolol Impurity 13 CAS 72224-25-0
| CAS No. | 72224-25-0 |
| Molecular Formula | C11H12O4 |
| Molecular Weight | 208.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Atenolol Impurity 13 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Atenolol Impurity 13 (CAS 72224-25-0, C11H12O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Atenolol Impurity 13 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 208.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H12O4 |
| Molecular Weight | 208.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
Related Atenolol Standards
- Atenolol USP Related Compound C (CAS 29122-69-8)
- Atenolol EP Impurity J (CAS 81346-71-6)
- Atenolol EP Impurity B (CAS 61698-76-8)
- Atenolol Impurity 14 (CAS 142037-04-5)
- Atenolol Impurity 12 (CAS 35198-42-6)
- Atenolol impurity 28 (CAS CATO-C4X-154928)
- Atenolol Impurity 25 (CAS CATO-C4X-154925)
- Atenolol EP Impurity D (CAS 115538-83-5)
Recommended Standards
- Tryptophan EP Impurity C (CAS 2922-83-0)
- Balsalazide Impurity 2 (CAS 7377-08-4)
- Tryptophan Impurity 14 (CAS 343-65-7)
- Lidocaine Impurity 77 (CAS CATO-C4X-167977)
- Pemafibrate Impurity 37 (CAS CATO-C4X-290337)
- Felodipine EP Impurity C (CAS 79925-38-5)
- Butylphthalide Impurity 84 (CAS CATO-C4X-181384)
- 2-(3-(Methoxymethyl)phenyl)cyclopropan-1-amine (CAS 1489751-32-7)
- 3-(3-Chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoic acid (CAS 1053658-50-6)
- 5-((Benzyloxy)carbonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-3-carboxylic acid (CAS 1286753-93-2)
- Benzoic acid acyl-β-D-glucuronide (CAS 19237-53-7)
- (R)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid (CAS 1251903-95-3)
- 2-(3,5-Dibromophenyl)-2-methylpropanenitrile (CAS 1096698-34-8)
- Semaglutide impurity 47 (CAS CATO-C4X-222647)
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