Estradiol Impurity 7 CAS 7291-41-0
| CAS No. | 7291-41-0 |
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Estradiol Impurity 7 is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Estradiol Impurity 7 (CAS 7291-41-0, C18H22O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Estradiol Impurity 7 (C18H22O2) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Estradiol Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
Related Estradiol Standards
- Estradiol Hemihydrate EP Impurity A (CAS 19973-76-3)
- Estradiol Impurity 2 (17beta-delta8,9-Dehydroestradiol) (CAS 23392-52-1)
- Estradiol EP Impurity D (CAS 791-69-5)
- Estradiol Impurity 21 (CAS 1187829-63-5)
- Estradiol Impurity 34 (CAS 3563-27-7)
- Estradiol Valerate Impurity 14 (CAS 57605-52-4)
- Estradiol Valerate Impurity 15 (CAS 55448-91-4)
- Estradiol Valerate Impurity 16 (CAS 57605-50-2)
Recommended Standards
- Oseltamivir Impurity 30 (CAS 212504-89-7)
- Doxylamine EP Impurity A (CAS 873407-01-3)
- Doxylamine Hydrogen Succinate EP Impurity A (CAS CATO-C4X-178921)
- Estriol EP Impurity B (Estrone) (CAS 53-16-7)
- Lubiprostone Impurity 24 (CAS 32233-41-3)
- Etoricoxib Impurity 14 (CAS 307531-95-9)
- Ursodeoxycholic acid impurity 63 (CAS 81873-91-8)
- 5-Methyl-2-phenyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridin-3-ol (CAS 1707371-91-2)
- 2-(4-Benzylpiperidin-1-yl)-N-(naphthalen-1-yl)acetamide (CAS 332114-59-7)
- 2-[(4-methoxyphenyl)methyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one (CAS 612530-85-5)
- Diethyl (1H,1H,2H,2H-heptadecafluorodec-1-yl)phosphonate (CAS 90146-96-6)
- 1-Phenyl-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione (CAS 15973-83-8)
- 4-Azatricyclo[5.2.2.0,2,6]undec-8-ene-3,5-dione (CAS 6715-29-3)
- Semaglutide Impurity 128 (CAS 2490269-78-6)
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