Estradiol EP Impurity D CAS 791-69-5
| CAS No. | 791-69-5 |
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Estradiol EP Impurity D (CAS 791-69-5, C18H22O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, Estradiol EP Impurity D is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 270.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Estradiol EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Estradiol Standards
- Estradiol Hemihydrate EP Impurity A (CAS 19973-76-3)
- Estradiol Impurity 2 (17beta-delta8,9-Dehydroestradiol) (CAS 23392-52-1)
- Estradiol Impurity 21 (CAS 1187829-63-5)
- Estradiol Impurity 34 (CAS 3563-27-7)
- Estradiol Impurity 7 (CAS 7291-41-0)
- Estradiol Valerate Impurity 14 (CAS 57605-52-4)
- Estradiol Valerate Impurity 15 (CAS 55448-91-4)
- Estradiol Valerate Impurity 16 (CAS 57605-50-2)
Recommended Standards
- Estriol EP Impurity B (Estrone) (CAS 53-16-7)
- Conjugated Estrogens EP Impurity K (CAS 651-55-8)
- Anastrozole Impurity 38 (CAS CATO-C4X-123938)
- Dapagliflozin Impurity 204 (CAS CATO-C4X-1138204)
- Linezolid USP Related Compound B (CAS 216868-57-4)
- Revefenacin Impurity 79 (CAS CATO-C4X-203179)
- Cefradine Impurity 29 (CAS CATO-C4X-121529)
- Azilsartan Impurity 175 (CAS CATO-C4X-1096175)
- 3-(Carboxy(4-(2-morpholino-2-oxoethyl)piperazin-1-yl)methyl)-1-methyl-1H-indole-5-carboxylic acid (CAS 1214646-55-5)
- 2,3,5,6-Tetramethylbenzonitrile (CAS 2571-53-1)
- Saikosaponin D (CAS 20874-52-6)
- 2-(Difluoromethyl)-4-iodo-3-(trifluoromethyl)pyridine-5-methanol (CAS 1807018-95-6)
- (2-Amino-3-methylphenyl)boronic acid (CAS 802836-52-8)
- [Tyr0] Fibrinopeptide A, human (CAS 103226-11-5)
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