Estriol EP Impurity B (Estrone) CAS 53-16-7
| CAS No. | 53-16-7 |
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Estriol EP Impurity B (Estrone) (C18H22O2) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Estriol EP Impurity B (Estrone) (CAS 53-16-7, C18H22O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Estriol EP Impurity B (Estrone) under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Estriol Standards
Recommended Standards
- Conjugated Estrogens EP Impurity K (CAS 651-55-8)
- Estradiol EP Impurity D (CAS 791-69-5)
- Anastrozole Impurity 38 (CAS CATO-C4X-123938)
- Estradiol Impurity 21 (CAS 1187829-63-5)
- Metoprolol Impurity 22 (CAS 123195-72-2)
- Rebamipide Impurity 41 (CAS CATO-C4X-152341)
- Cobicistat impurity 8 (CAS CATO-C4X-18168)
- 1-(2-(4-Bromophenyl)azetidin-1-yl)ethanone (CAS 1467060-80-5)
- 3-Chloro-N-(2,4-dibromophenyl)benzamide (CAS 548790-40-5)
- 2-((Tert-butoxycarbonyl)amino)-3-(1-methyl-1H-pyrazol-4-yl)propanoic acid (CAS 942317-54-6)
- 2-(3,4-Dichlorophenyl)acetimidamide (CAS 55154-91-1)
- Pyridazine N-Oxide (CAS 1457-42-7)
- Boc-Arg(Z)-OH (CAS 51219-18-2)
- Semaglutide impound 212 (CAS CATO-C4X-2226212)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com