8-methoxy-2-(trifluoromethyl)quinoline-5-carbonyl chloride CAS 737740-52-2
| CAS No. | 737740-52-2 |
| Molecular Formula | C12H7ClF3NO2 |
| Molecular Weight | 289.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 8-methoxy-2-(trifluoromethyl)quinoline-5-carbonyl chloride is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
8-methoxy-2-(trifluoromethyl)quinoline-5-carbonyl chloride (CAS 737740-52-2), molecular formula C12H7ClF3NO2 and molecular weight 289.64 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 8-methoxy-2-(trifluoromethyl)quinoline-5-carbonyl chloride (C12H7ClF3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 289.64 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 8-methoxy-2-(trifluoromethyl)quinoline-5-carbonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H7ClF3NO2 |
| Molecular Weight | 289.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 6-Chloro-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine (CAS 714962-04-6)
- Ethyl 4-chloro-6,7,8-trifluoroquinoline-3-carboxylate (CAS 207231-24-1)
- 6-Chloro-5-(3-(trifluoromethyl)phenyl)pyridine-2,4-diol (CAS 477864-71-4)
- Haloxyfop-phenol Metabolite (CAS 69045-89-2)
- 2-Chloro-N-(2-ethylphenyl)acetamide (CAS 57503-02-3)
- 3,3',5'-Tricarboxylic biphenyl (CAS 863495-62-9)
- 4-Ethoxy-3-(trifluoromethyl)benzoyl chloride (CAS 647010-69-3)
- 4-Methoxyphenylboronic Acid Pinacol Ester (CAS 171364-79-7)
- 3-(Pyridin-4-yl)-1H-indazol-5-amine dihydrochloride (CAS 1427195-08-1)
- Ethyl 3-amino-2-(cyclopentylmethyl)propanoate (CAS 1247195-02-3)
- 1-(2-(Tert-butylthio)ethyl)-1h-pyrazol-4-amine (CAS 1248365-25-4)
- Hexyl furan-2-carboxylate (CAS 39251-86-0)
- 6-Chloro-N,N-dimethyl-2-(trifluoromethyl)-4-pyrimidinamine (CAS 866648-53-5)
- Semaglutide impurity 76 (CAS CATO-C4X-222676)
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