Indometacin Impurity 26 CAS CATO-C4X-147026
| CAS No. | CATO-C4X-147026 |
| Molecular Formula | C10H11ClO3 |
| Molecular Weight | 214.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Indometacin Impurity 26 (C10H11ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 214.65 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Indometacin Impurity 26 (CAS CATO-C4X-147026, C10H11ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Indometacin Impurity 26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H11ClO3 |
| Molecular Weight | 214.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Indometacin Standards
- Indometacin Impurity 25 (CAS CATO-C4X-147025)
- Indometacin Impurity 17 (CAS 10414-67-2)
- Indometacin EP Impurity B (CAS 2882-15-7)
- Indometacin Impurity 20 (CAS 73301-01-6)
- Indometacin Impurity 27 (CAS CATO-C4X-147027)
- Indometacin Impurity 36 (CAS CATO-C4X-147036)
- Indometacin Impurity 46 (CAS CATO-C4X-147046)
- Indometacin EP Impurity C (CAS 4018-82-0)
Recommended Standards
- Opicapone Impurity 43 (CAS CATO-C4X-240443)
- Bisoprolol Impurity 51 (CAS 62911-12-0)
- Meclofenoxate Impurity 1 (CAS 14426-42-7)
- Lenvatinib Impurity 105 (CAS CATO-C4X-1140105)
- Ozenoxacin Impurity 75 (CAS CATO-C4X-279675)
- Nicotinamide Impurity 10 (CAS 23111-00-4)
- Nilotinib Impurity 49 (CAS CATO-C4X-125649)
- Cefadroxil EP Impurity A(Amoxicillin EP Impurity I) (CAS 22818-40-2)
- 2-(Trifluoromethyl)benzo[d]oxazole (CAS 2008-04-0)
- D-Talose (CAS 2595-98-4)
- 2,2'-((7-Chloro-9H-fluoren-2-yl)azanediyl)diethanol (CAS 6583-86-4)
- 4,6-Difluoro-N-(pyridin-2-ylmethyl)-1,3-benzothiazol-2-amine (CAS 1105191-11-4)
- (2-Ethylbicyclo[2.2.1]heptan-2-yl)methanamine (CAS 1561971-30-9)
- Semaglutide impurity 99 (CAS CATO-C4X-222699)
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