Indometacin Impurity 17 CAS 10414-67-2
| CAS No. | 10414-67-2 |
| Molecular Formula | C9H7ClO4 |
| Molecular Weight | 214.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Indometacin Impurity 17 (C9H7ClO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Indometacin Impurity 17 (CAS 10414-67-2), a pharmacopoeial impurity reference standard (molecular formula C9H7ClO4, MW 214.60 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7ClO4 |
| Molecular Weight | 214.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
Related Indometacin Standards
- Indometacin Impurity 25 (CAS CATO-C4X-147025)
- Indometacin Impurity 26 (CAS CATO-C4X-147026)
- Indometacin EP Impurity B (CAS 2882-15-7)
- Indometacin Impurity 20 (CAS 73301-01-6)
- Indometacin Impurity 27 (CAS CATO-C4X-147027)
- Indometacin Impurity 36 (CAS CATO-C4X-147036)
- Indometacin Impurity 46 (CAS CATO-C4X-147046)
- Indometacin EP Impurity C (CAS 4018-82-0)
Recommended Standards
- Sodium 4-chlorobenzenesulfonate (CAS 5138-90-9)
- Dotinurad Impurity 211 (CAS 70679-89-9)
- Methyl 5-chloro-3-formyl-2-hydroxybenzoate (CAS 87633-23-6)
- Dotinurad Impurity 214 (CAS CATO-C4X-2494214)
- Upadacitinib Impurity 1 (CAS CATO-C4X-24051)
- Ibrutinib Impurity 182 (CAS CATO-C4X-1064182)
- Fluconazole Impurity 61 (CAS CATO-C4X-101961)
- (R)-2-(3-fluoro-4-methylphenyl)piperidine (CAS 1241680-10-3)
- ((Dimethylstannanediyl)bis(sulfanediyl))bis(ethane-2,1-diyl) didodecanoate (CAS 68928-42-7)
- 3-Bromo-4-iodopyrazole (CAS 27258-15-7)
- 2-bromo-1-(methoxymethyl)-4-methylbenzene (CAS 1824417-66-4)
- (4-Methylthiazol-2-yl)(phenyl)methanamine (CAS 764617-68-7)
- N-(4-Amino-phenyl)-3-methoxy-propionamide (CAS 91761-09-0)
- Peptide-GMF (CAS CATO-CPTD788469)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com