Indometacin Impurity 25 CAS CATO-C4X-147025
| CAS No. | CATO-C4X-147025 |
| Molecular Formula | C10H11ClO3 |
| Molecular Weight | 214.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Indometacin Impurity 25 (C10H11ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Indometacin Impurity 25 (CAS CATO-C4X-147025) is a certified pharmaceutical impurity reference standard with the molecular formula C10H11ClO3 and a molecular weight of 214.65 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11ClO3 |
| Molecular Weight | 214.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Indometacin Standards
- Indometacin Impurity 26 (CAS CATO-C4X-147026)
- Indometacin Impurity 17 (CAS 10414-67-2)
- Indometacin EP Impurity B (CAS 2882-15-7)
- Indometacin Impurity 20 (CAS 73301-01-6)
- Indometacin Impurity 27 (CAS CATO-C4X-147027)
- Indometacin Impurity 36 (CAS CATO-C4X-147036)
- Indometacin Impurity 46 (CAS CATO-C4X-147046)
- Indometacin EP Impurity C (CAS 4018-82-0)
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