Neratinib Impurity 51 CAS CATO-C4X-113451
| CAS No. | CATO-C4X-113451 |
| Molecular Formula | C12H9ClN2O2 |
| Molecular Weight | 248.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Neratinib Impurity 51 (CAS CATO-C4X-113451), a pharmacopoeial impurity reference standard (molecular formula C12H9ClN2O2, MW 248.67 g/mol) used for the identification and quantification of trace impurities in APIs.
Neratinib Impurity 51 (C12H9ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO manufactures Neratinib Impurity 51 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H9ClN2O2 |
| Molecular Weight | 248.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Neratinib Standards
- Neratinib Impurity 25 (CAS 848133-87-9)
- Neratinib Impurity 52 (CAS CATO-C4X-113452)
- Neratinib Impurity 43 (CAS 1222172-49-7)
- Neratinib Impurity 60 (CAS CATO-C4X-113460)
- Neratinib Impurity 58 (CAS CATO-C4X-113458)
- Neratinib Impurity 41 (CAS 1201080-20-7)
- Neratinib Impurity 38 (CAS 2240142-43-0)
- Neratinib Impurity 23 (CAS 524955-09-7)
Recommended Standards
- Sorafenib impurity 65 (CAS CATO-C4X-112465)
- Clofazimine Impurity 10 (CAS CATO-C4X-207110)
- 5-chloro-2-nitro-N-phenylaniline (CAS 25781-92-4)
- Clofazimine Impurity 11 (CAS 74002-27-0)
- Capecitabine Impurity 26 (CAS 1262133-69-6)
- Relmapirazin diastereoisomer Impurity (CAS CATO-C4X-33344)
- Quetiapine Impurity 54 (CAS 4171-83-9)
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- 5-Chloro-3-(difluoromethyl)pyridin-2(1H)-one (CAS 1805305-15-0)
- 3-Amino-3-(1-methyl-1H-imidazol-2-yl)propanamide (CAS 771521-47-2)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com