Clofazimine Impurity 18 CAS CATO-C4X-207118
| CAS No. | CATO-C4X-207118 |
| Molecular Formula | C12H8ClN3O3 |
| Molecular Weight | 277.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Clofazimine Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Clofazimine Impurity 18 (CAS CATO-C4X-207118), a pharmacopoeial impurity reference standard (molecular formula C12H8ClN3O3, MW 277.66 g/mol) used for the identification and quantification of trace impurities in APIs.
Clofazimine Impurity 18 (C12H8ClN3O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C12H8ClN3O3 |
| Molecular Weight | 277.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Clofazimine Standards
- Clofazimine Impurity 10 (CAS CATO-C4X-207110)
- Clofazimine Impurity 11 (CAS 74002-27-0)
- Clofazimine Impurity 5 (CAS 23008-56-2)
- Clofazimine Impurity 8 (CAS 138452-44-5)
- Clofazimine Impurity 19 (CAS CATO-C4X-207119)
- Clofazimine Impurity 15 (CAS CATO-C4X-207115)
- Clofazimine Impurity 4 (CAS CATO-C4X-20714)
- Clofazimine Impurity 16 (CAS CATO-C4X-207116)
Recommended Standards
- 5-Chlorocytidine (CAS 25130-29-4)
- 6-Chloro-2-isobutyl-4-(trifluoromethyl)-2h-pyrazolo[3,4-b]pyridine (CAS 1018127-90-6)
- 5-Chloro-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-imidazole-4-carboxamide (CAS 59353-97-8)
- 6-Chloro-3-methyl-2-propyl-4-(trifluoromethyl)-2h-pyrazolo[3,4-b]pyridine (CAS 1018165-22-4)
- Baricitinib Impurity 28 (CAS CATO-C4X-226028)
- Maxacalcitol Impurity 11 (CAS 142785-55-5)
- Rosuvastatin Impurity 156 (CAS CATO-C4X-1169156)
- 3-((1R,3R)-3-(((R)-2-(3-Chlorophenyl)-2-hydroxyethyl)amino)cyclohexyl)phenol (CAS 190063-23-1)
- Triethyl Isocitrate (Mixture of Diastereomers) (CAS 16496-37-0)
- 3-(2-Methoxy-2-oxoethoxy)phenylboronic acid (CAS 1256355-55-1)
- 2-(Trifluoromethyl)quinoline 2-Trifluoromethyl-quinoline 347-42-2 A25656 (CAS 347-42-2)
- Methyl 4-amino-[1,1'-biphenyl]-3-carboxylate (CAS 243989-52-8)
- Fmoc-N-allyl-hydroxylamine (CAS 198411-65-3)
- Insulin Lispro (CAS 133107-64-9)
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