Colchicine EP Impurity A CAS 7411-12-3

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.7411-12-3
Molecular FormulaC21H23NO6
Molecular Weight385.41 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Colchicine EP Impurity A CAS 7411-12-3 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 385.41 g/mol gives Colchicine EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Colchicine EP Impurity A (CAS 7411-12-3) is a certified pharmaceutical impurity reference standard with the molecular formula C21H23NO6 and a molecular weight of 385.41 g/mol.

Based on its molecular formula C21H23NO6, Colchicine EP Impurity A contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 385.41 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Colchicine EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC21H23NO6
Molecular Weight385.41 g/mol
AppearancePale yellow to yellow crystalline powder
Purity>90%
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)11.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1959
Nitrogen Atoms1

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