Colchicine EP Impurity E CAS 7336-33-6
| CAS No. | 7336-33-6 |
| Molecular Formula | C21H23NO6 |
| Molecular Weight | 385.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Colchicine EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Colchicine EP Impurity E (CAS 7336-33-6, C21H23NO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H23NO6, Colchicine EP Impurity E contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 385.41 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H23NO6 |
| Molecular Weight | 385.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 1 |
Related Colchicine Standards
- Colchicine EP Impurity A (CAS 7411-12-3)
- Colchicine EP Impurity F (CAS 477-27-0)
- Colchicine Impurity 8 (CAS 6877-25-4)
- Colchicine Racemic Mixture Impurity (CAS 54192-66-4)
- rac-Colchicine, >98% (CAS 209810-38-8)
- (R)-Colchicine (CAS 75520-89-7)
- Colchicine EP Impurity B (CAS CATO-C4X-141112)
- Colchicine EP Impurity C (CAS 6901-13-9)
Recommended Standards
- Mivacurium chloride Impurity 40 (CAS CATO-C4X-137540)
- Naltrexone Impurity 21 (CAS 64643-76-1)
- Valaciclovir Impurity 55 (CAS CATO-C4X-124855)
- Nicardipine Impurity 48 (CAS CATO-C4X-171048)
- Tolvaptan Impurity 20 (CAS 137982-91-3)
- Lifitegrast Impurity 115 (CAS CATO-C4X-2409115)
- Carbidopa EP Impurity G (CAS 2503-44-8)
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