Colchicine EP Impurity F CAS 477-27-0
| CAS No. | 477-27-0 |
| Molecular Formula | C21H23NO6 |
| Molecular Weight | 385.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Colchicine EP Impurity F is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Colchicine EP Impurity F (CAS 477-27-0), a pharmacopoeial impurity reference standard (molecular formula C21H23NO6, MW 385.41 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Colchicine EP Impurity F is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 385.41 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Colchicine EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H23NO6 |
| Molecular Weight | 385.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Colchicine Standards
- Colchicine EP Impurity A (CAS 7411-12-3)
- Colchicine EP Impurity E (CAS 7336-33-6)
- Colchicine Impurity 8 (CAS 6877-25-4)
- Colchicine Racemic Mixture Impurity (CAS 54192-66-4)
- rac-Colchicine, >98% (CAS 209810-38-8)
- (R)-Colchicine (CAS 75520-89-7)
- Colchicine EP Impurity B (CAS CATO-C4X-141112)
- Colchicine EP Impurity C (CAS 6901-13-9)
Recommended Standards
- Naltrexone Impurity 21 (CAS 64643-76-1)
- Nicardipine Impurity 48 (CAS CATO-C4X-171048)
- Mivacurium chloride Impurity 40 (CAS CATO-C4X-137540)
- Mirogabalin Acyle Glucuronide (CAS CATO-CP155156)
- Ketoprofen Impurity 94 (CAS CATO-C4X-147194)
- Carboprost Impurity 6 (CAS CATO-C4X-21036)
- Anastrozole EP Impurity E (CAS 120511-88-8)
- 4-(Tert-butyl)cycloheptane-1-sulfonamide (CAS 1492776-64-3)
- 3-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid (CAS 773124-24-6)
- 2-Hydroxy-3-phenoxypropyl methacrylate (CAS 16926-87-7)
- 3-(4-Bromophenyl)-2-oxopropanoic acid (CAS 38712-59-3)
- 5-(Bromomethyl)-2-propylpyrimidine (CAS 1823380-14-8)
- Fexinidazole (CAS 59729-37-2)
- Bax inhibitor peptide V5 (CAS 579492-81-2)
Why CATO?
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