Propofol EP Impurity O CAS 74663-48-2

Description

Compared with other compounds in its class, the molecular weight of 178.27 g/mol gives Propofol EP Impurity O distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Propofol EP Impurity O (CAS 74663-48-2) is a certified pharmaceutical impurity reference standard with the molecular formula C12H18O and a molecular weight of 178.27 g/mol.

Propofol EP Impurity O (C12H18O) contains a hydroxyl group, an ether linkage, an aromatic ring system. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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