Clobetasol Propionate EP Impurity K CAS 75883-07-7
| CAS No. | 75883-07-7 |
| Molecular Formula | C25H33FO6 |
| Molecular Weight | 448.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clobetasol Propionate EP Impurity K.
Clobetasol Propionate EP Impurity K (CAS 75883-07-7) is a certified pharmaceutical impurity reference standard with the molecular formula C25H33FO6 and a molecular weight of 448.52 g/mol.
Clobetasol Propionate EP Impurity K (C25H33FO6) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Clobetasol Propionate EP Impurity K meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H33FO6 |
| Molecular Weight | 448.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F-containing |
Related Clobetasol Standards
- Clobetasol Propionate EP Impurity A (CAS 5534-13-4)
- Clobetasol Propionate EP Impurity J (CAS 1486466-31-2)
- Clobetasol Propionate Impurity 19 (CAS CATO-C4X-159219)
- Clobetasol Propionate Impurity (21-Chloro-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione) (CAS 95796-50-2)
- Clobetasol Propionate EP Impurity E (CAS CATO-C4X-159214)
- Clobetasol Propionate EP Impurity H (CAS 4351-48-8)
- Clobetasol Propionate EP Impurity C (CAS 25122-52-5)
- Clobetasol Propionate (CAS 25122-46-7)
Recommended Standards
- Pazopanib Impurity 16 (CAS CATO-C4X-172516)
- Triamcinolone Acetonide Impurity 49 (CAS 7704-77-0)
- Fluocinolone Acetonide Impurity 42 (CAS 3793-12-2)
- tert-butyl N-(tert-butoxycarbonylamino)-N-[3-[4-(trifluoromethyl)phenyl]-1-bicyclo[1.1.1]pentanyl]carbamate (CAS 2149634-49-9)
- Norethisterone EP Impurity C (CAS 22933-71-7)
- Selexipag Impurity 55 (CAS CATO-C4X-196155)
- Olmesartan Impurity 28 (CAS 114772-53-1)
- 2-(3,5-Dichlorophenyl)benzo[d]thiazole (CAS 391219-75-3)
- N-(4-bromo-2,6-dimethylphenyl)-1,1-diphenylmethanimine (CAS 849438-97-7)
- Tert-butyl ((4R,5S)-2,2,4-trimethyl-1,3-dioxan-5-yl)carbamate (CAS 1932023-27-2)
- 2-Amino-n-(5-chloropyridin-2-yl)benzamide (CAS 280771-61-1)
- N1,5-Dimethylbenzene-1,2,4-triamine (CAS 97902-54-0)
- 4,8-Bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-1H,3H-benzo[1,2-c:4,5-c']bis([1,2,5]thiadiazole) (CAS 1003593-65-4)
- Tirzepatide Impurity 16 (CAS CATO-C4X-324016)
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