Clobetasol Propionate EP Impurity E CAS CATO-C4X-159214
| CAS No. | CATO-C4X-159214 |
| Molecular Formula | C25H33ClO4 |
| Molecular Weight | 432.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Clobetasol Propionate EP Impurity E is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Clobetasol Propionate EP Impurity E (CAS CATO-C4X-159214), a pharmacopoeial impurity reference standard (molecular formula C25H33ClO4, MW 432.98 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Clobetasol Propionate EP Impurity E (C25H33ClO4) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 432.98 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clobetasol Propionate EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H33ClO4 |
| Molecular Weight | 432.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Clobetasol Standards
- Clobetasol Propionate EP Impurity H (CAS 4351-48-8)
- Clobetasol Propionate EP Impurity A (CAS 5534-13-4)
- Clobetasol Propionate EP Impurity K (CAS 75883-07-7)
- Clobetasol Propionate EP Impurity J (CAS 1486466-31-2)
- Clobetasol Propionate Impurity 19 (CAS CATO-C4X-159219)
- Clobetasol Propionate Impurity (21-Chloro-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione) (CAS 95796-50-2)
- Clobetasol-d5 (CAS CATO-CCAD303553)
- Clobetasol Propionate Impurity 20 (CAS CATO-C4X-159220)
Recommended Standards
- 3-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid (CAS 3734-24-5)
- Liothyronine EP Impurity B (CAS 300-39-0)
- 3,5-Diiodo-DL-tyrosine (CAS 66-02-4)
- Luliconazole Impurity 12 (CAS CATO-C4X-285312)
- Nimodipine Impurity 20 (CAS CATO-C4X-138520)
- Esmolol Impurity 83 (CAS CATO-C4X-189183)
- Ioversol Impurity 20 (CAS CATO-C4X-209120)
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