Clobetasol Propionate EP Impurity A CAS 5534-13-4

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.5534-13-4
Molecular FormulaC25H33FO6
Molecular Weight448.52 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Clobetasol Propionate EP Impurity A CAS 5534-13-4 chemical structure

Description

The occurrence of Clobetasol Propionate EP Impurity A is closely related to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Clobetasol Propionate EP Impurity A (CAS 5534-13-4), a pharmacopoeial impurity reference standard (molecular formula C25H33FO6, MW 448.52 g/mol) used for the identification and quantification of trace impurities in APIs.

Based on its molecular formula C25H33FO6, Clobetasol Propionate EP Impurity A contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 448.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Clobetasol Propionate EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC25H33FO6
Molecular Weight448.52 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor)
Purity>95%
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1958
Halogen ContentF-containing

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