Clobetasol Propionate EP Impurity H CAS 4351-48-8
| CAS No. | 4351-48-8 |
| Molecular Formula | C25H33FO5 |
| Molecular Weight | 432.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Clobetasol Propionate EP Impurity H (CAS 4351-48-8), a pharmacopoeial impurity reference standard (molecular formula C25H33FO5, MW 432.52 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution, Clobetasol Propionate EP Impurity H is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 432.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clobetasol Propionate EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H33FO5 |
| Molecular Weight | 432.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
Related Clobetasol Standards
- Clobetasol Propionate EP Impurity E (CAS CATO-C4X-159214)
- Clobetasol Propionate EP Impurity A (CAS 5534-13-4)
- Clobetasol Propionate EP Impurity K (CAS 75883-07-7)
- Clobetasol Propionate EP Impurity J (CAS 1486466-31-2)
- Clobetasol Propionate Impurity 19 (CAS CATO-C4X-159219)
- Clobetasol Propionate Impurity (21-Chloro-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione) (CAS 95796-50-2)
- Clobetasol-d5 (CAS CATO-CCAD303553)
- Clobetasol Propionate Impurity 20 (CAS CATO-C4X-159220)
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- tert-Butyl (S)-2-(4-(tert-butyl)phenyl)piperazine-1-carboxylate (CAS 1260592-89-9)
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Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com